Infectious diseases account for second largest cause of deaths worldwide. Continuing progress in treatment of many infections mainly in hospitals and community settings is now threatened by the increasing numbers and widening distribution of pathogens resistant to antimicrobial drugs. The problem is severely cumulated by the lack of progress in antibiotic innovation during the past two decades broadly due to its complex nature of discovery process.
The challenges encountered by anti-infective research, unlike any other therapeutic area is to have multiple targets in terms of bacterial species and multiple different infection types. Understanding the complexity is a key element in managing the success of antimicrobial drug discovery.
Aravali Pharma consultants have in-depth knowledge and hands-on experience with all stages of anti-infective drug discovery which would help in articulating the problem statement and designing an appropriate solution.
- Project initiation and foreseeing
- Drafting pre-clinical development plans
- Validation of novel anti-infective targets
- Antimicrobial Resistance (AMR)
- Strategize and optimize pre-clinical anti-infective portfolios
- Target Product Profile (TPP): drafting and updating
- Gap analysis
- Opportunity assessment of NCEs
- Pre-clinical screening
- Layout plans and strategies for screening small molecules
- Combination effect
- Frequency of Resistance (FOR)
- Mutation Prevention Concentration (MPC)
- PK/PD analysis
- Reviews
- Data, documents, protocols, report and scientific literature
- Due diligence
- Assessment of scientific literature